Applying to UORSY general fragments more strict criteria based on the recent reports1,2 and in-house findings, we created “cream of the crop” library of 279 fragment-like molecules that comply with “Rule of Three”, PAINS- and “overused” motifs-free, and are highly dissimilar to the commercially available fragments (Figure 1).
Figure 1. Similarity analysis of UORSY selected fragments.
140<MW<230; HbA≤3; HbD≤3; logP≤3; RotBonds≤3.
UORSY selected fragments are is available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by 1H NMR; analytical data is provided.
For more information, please contact us at firstname.lastname@example.org
1C. W. Murray, D. C. Rees, Angew. Chemie Int. Ed. 2016, 55, 488–492.
2G. M. Keserű et al, J. Med. Chem. 2016, 59, 8189–8206.
Fill in the form to ask a question.