Starting from discovery of penicillin in 1928, antibiotics have become essential drugs, if not for them we would return to medieval death-rate. But growing resistance in bacteria requires new medicines to fight microbes. No splash in this area of research, however, has been observed since the golden age in 1940-1960s: most classes of antibiotics have been discovered before 1987.1
A remained need for starting points to novel antibacterial drugs motivated us to create UORSY antibacterial library.
Designing the library, we aimed to efficiently represent chemical space of the antibacterials for effective hit-finding. To achieve this, we selected compounds based on similarity to the known antibacterial agents (ECFP4 fingerprints, Tanimoto score > 0.7) and on novel chemotypes with favorable physicochemical profiles.2
Features of UORSY antibacterial library:
- 6293 compounds
Figure 1. Analogues of the antibacterials to fill the gaps in the known space
Figure 2. Novel chemotypes with antibacterial-like physicochemical profiles to explore the unknown space
UORSY antibacterial library is available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by 1H NMR; analytical data is provided.
For more information, please contact us at firstname.lastname@example.org
1 Cynthia C. Knapp and John A. Washington, Antimicrob Agents Chemother, 1986, 30(6), 938-939.
2 O'Shea R, Moser HE, J Med Chem, 2008, 51(10), 871-878.
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