UORSY CNS-permeable Compounds

CNS-targeted drugs differ from the non-CNS-targeted molecules in their physicochemical profiles and structural properties. The former compounds have to be more rigid and to have lower TPSA and logP for being able to cross Blood-brain barrier (BBB).

Implementing the literature data,1 Ro3, and our in-house parameters, we created a library of 2589 unique compounds that meet CNS-like criteria. The current set will be a good starting point for drug discovery projects related to CNS-active molecules.

     

Physicochemical profiles of UORSY CNS-permeable compounds:

200<MW<350; HbA≤3; HbD≤2; 2<logP<4; 0.25<Fsp3<1; RotBonds≤6; 15<TPSA<60; (N+O)≤3.

UORSY CNS-permeable compounds are available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by 1H NMR; analytical data is provided.

For more information, please contact us at screenlibs@uorsy.com

1Pajouhesh, H.; Lenz, G. R., NeuroRx 2005, 2, 541–553.

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