For a range of therapeutic targets, macrocycles could be isolated from natural sources. However, the variety of macrocyclic natural products is limited, thus synthetic approaches to macrocycles are needed. To address the issue of availability of diverse macrocyclic molecules, we have developed UORSY Feasible Macrocyclic Scaffold Library (FMSL). Chemically, the design of FMSL relies on the availability of reagents for both, 1) macrocyclic scaffold synthesis (by a synthetic chemist, based on our in-house experience), and 2) derivatization of the scaffold moieties with stoppers (using parallel synthesis approach). The macrocyclic scaffolds have one or two points of variation affording a highly diverse library.
