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UORSY
F-fragments

Absence of fluorine in natural background has pushed exploration of F-containing fragments and enabled simple screening protocols: ¹⁹F NMR-based fragment screening has been a useful tool for hit detection and further optimization.¹

At UORSY, we have created a library of fluorine fragments that contains compounds with favorable physicochemical profiles and unique motifs (Figure 1). The library complies with “Rule of 3” and recently introduced criteria.²

Figure 1. Solubility analysis (left) and similarity analysis (right) of UORSY F fragments.

Physicochemical profiles of UORSY F fragments:

122<MW<300;   HbA≤3;   HbD≤2;   logP≤4;   RotBonds≤3.

UORSY F fragments are available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by ¹H NMR; analytical data is provided. For more information, please contact us at screenlibs@uorsy.com

¹ Vulpetti, A.; Dalvit, C., ChemMedChem 2013, 8, 2057–2069.
² Jordan, J.et al,  J. Med. Chem. 2012, 55, 678–687.