Applying to UORSY general fragments more strict criteria based on the recent reports1,2 and in-house findings, we created “cream of the crop” library of fragment-like molecules that comply with Astex “Rule of Three”, PAINS- and “overused” motifs-free, and are highly dissimilar to the commercially available fragments (Figure 1).
Figure 1. Similarity analysis of UORSY selected fragments.
140<MW<230; HbA≤3; HbD≤3; logP≤3; RotBonds≤3.
UORSY selected fragments are is available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by 1H NMR; analytical data is provided.
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1C. W. Murray, D. C. Rees, Angew. Chemie Int. Ed. 2016, 55, 488–492.
2G. M. Keserű et al, J. Med. Chem. 2016, 59, 8189–8206.
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