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UORSY Saturated Compounds

“Escape from Flatland” concept means library enrichment with entities having high fraction of sp³-hibridized carbon atoms, in order to increase molecular complexity, solubility, and permeability, and decrease toxicity. Implementing the literature-based¹ parameters and our internal structural and physicochemical filters, we created a library of compounds based on unique saturated cores.

Physicochemical profiles of UORSY saturated compounds:

200<MW<350; HbA≤8; HbD≤4; -1<logP<3; 0.4<Fsp³<1; RotBonds≤7; 10<TPSA<120; 14<HAC<26.

UORSY saturated compounds are available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by ¹H NMR; analytical data is provided.

For more information, please contact us at screenlibs@uorsy.com

¹Lovering, F.; Bikker, J.; Humblet, C., J. Med. Chem. 2009, 52, 6752–6756.