SH2 (Src Homology 2) domains are protein-protein interaction domains, which consist of sequence-specific the phosphor tyrosine-binding amino acid modules.1 Over one hundred SH2 domains presented in numerous signaling pathways are reported.2 Modulation of SH2 has a range of perspective due to their role in diseases.3 For the creation of our SH2 domain modulators library, we utilized molecular docking. All known SH2 domains were initially clustered into 8 groups. For each group, a centroid was determined and a collection of our in-stock compounds was screened against 8 centroids in silico.
UORSY SH2 domain modulators library is available in stock and could be delivered within 2 weeks in any customer-preferred format: as powders, dry films or DMSO solutions formatted in vials, 96 or 384-well plates. All compounds have a minimum purity of 90% assessed by 1H NMR; analytical data is provided.
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1Filippakopoulos, P.; Müller, S.; Knapp, S. Curr. Opin. Struct. Biol. 2009, 19, 643–649.
2Wavreille, A.-S.; Garaud, M.; Zhang, Y.; Pei, D. Methods 2007, 42, 207–219.
3Jin, L. L.; Wybenga-Groot, L. E.; Tong, J.; Taylor, P.; Minden, M. D.; Trudel, S.; McGlade, C. J.; Moran, M. F. Mol. Cell. Proteomics 2015, 14, 695–706.
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